Researcher at Erciyes University, Turkey
Prof. Minoo Rassoulzadegan is an internationally acclaimed molecular geneticist renowned for her pioneering work in epigenetic inheritance and RNA-mediated heredity. With over four decades of research experience, she has redefined the classical boundaries of inheritance by introducing concepts such as paramutation and transvection in mammals—phenomena traditionally known in plant systems. As a former CNRS Director of Research and current faculty at Erciyes University in Turkey, her work continues to influence genetic and developmental biology across species. She has published extensively in prestigious journals including Nature, Developmental Cell, and PLoS Genetics, among others. Her groundbreaking discovery that RNA molecules in sperm can transmit epigenetic traits across generations has not only challenged Mendelian genetics but also opened new frontiers in disease inheritance, behavioral neuroscience, and environmental epigenetics. Prof. Rassoulzadegan is also a revered mentor, having guided numerous researchers globally. Her research bridges plants and mammals, showing the evolutionary continuity of epigenetic mechanisms.
Professional Profile
Education
Prof. Rassoulzadegan began her academic journey in France at Nice University – Faculty of Sciences, where she earned her Bachelor’s (BS) degree in Biology between 1972 and 1975. She continued her studies there with a Master of Science (MSc) in Biochemistry from 1975 to 1976, followed by a PhD in Molecular Genetics, which she completed in 1979. Her academic training laid a strong foundation in biological systems, with a special focus on the molecular underpinnings of genetic regulation. Her doctoral work laid the groundwork for her later paradigm-shifting research in mouse genetics and epigenetic control. This progression through biology, biochemistry, and molecular genetics provided her with an interdisciplinary framework that allowed her to bridge knowledge across species. She later supplemented her training with specialized studies in embryonic manipulation at Cold Spring Harbor Laboratory (USA) in 1984—an experience that further refined her techniques in early developmental biology and germline research.
Professional Experience
Prof. Rassoulzadegan has held influential research and academic positions throughout her career. She began as an Attaché de Recherche in 1979 with the CNRS (Centre National de la Recherche Scientifique) and rose through the ranks to become Directrice de Recherche by 1986. From 2004 to 2011, she served as Director of Inserm Unit 636, leading innovative research in RNA biology and epigenetics. Since 2012, she has been a Group Leader at the Institut de Biologie Valrose (IBV) in France and has remained scientifically active even after moving to Erciyes University in Turkey. Her professional journey is marked by leadership in both research direction and scientific mentorship. She has collaborated with world-renowned scientists and played a crucial role in shaping understanding of genetic regulation through RNA. Her transnational academic career reflects her status as a global scientific ambassador and role model in the life sciences community.
Research Interests
Prof. Rassoulzadegan’s research interests lie at the cutting edge of molecular genetics, epigenetics, RNA biology, and transgenerational inheritance. Her primary focus has been on understanding how small RNAs in sperm and other germline cells contribute to non-Mendelian patterns of inheritance. Her groundbreaking discovery that RNA molecules can carry hereditary information and influence phenotype has revolutionized genetics. She investigates mechanisms of paramutation, a form of epigenetic regulation initially characterized in plants, and was among the first to demonstrate its existence in mammals. Her work also extends into the role of epigenetic changes in diseases such as obesity, metabolic disorders, neurodevelopmental conditions like autism, and stress-related endocrine dysfunction. Lately, she has expanded her interest into RNA-based biomarkers, exploring their potential in predictive medicine and reproductive health. Her research embodies a convergence of basic science and translational relevance, drawing conceptual parallels between plant and animal models of heredity.
Research Skills
Prof. Rassoulzadegan is equipped with a powerful arsenal of research skills encompassing molecular cloning, mouse model development, embryonic microinjection, RNA isolation, epigenetic profiling, transcriptomics, and bioinformatics. She has mastered advanced CRISPR-Cas9 genome editing techniques, and her laboratory routinely generates transgenic mouse models to study the heritability of RNA signatures. Her expertise extends to small RNA sequencing, analysis of DNA methylation, histone modifications, and non-coding RNA function in germline cells. A critical aspect of her skill set lies in her ability to design cross-species experiments that model human diseases and test her hypotheses of RNA-mediated inheritance. She is also proficient in data interpretation tools used in systems biology and functional genomics. Her lab has pioneered several in vivo and in vitro assays to dissect complex hereditary signals, making her not only a theoretician but also an experimentalist of the highest order.
Awards and Honors
Prof. Rassoulzadegan’s scientific excellence has earned her multiple prestigious honors. Most notably, she was elected as a Member of the European Molecular Biology Organization (EMBO) in 2009, a recognition given only to the most accomplished life scientists in Europe. Her work has been extensively cited and celebrated in top-tier journals, garnering respect from across the biomedical and plant research communities. She has been invited as a keynote speaker at numerous international conferences and has served on editorial boards of reputed journals in genetics and molecular biology. Her legacy also includes mentorship of emerging scientists, many of whom have gone on to become leaders in genetics, epigenetics, and developmental biology. Her continuous innovation, global research engagement, and visionary contributions to science underscore her status as a trailblazer in RNA epigenetics and inheritance.
Conclusion
Prof. Dr. Minoo Rassoulzadegan is a visionary and highly accomplished scientist whose discoveries in RNA-mediated epigenetic inheritance have profoundly influenced both plant and animal genetics. While her core domain is molecular biology and mammalian epigenetics, the conceptual origin and translational relevance of her work to plant sciences make her a strong and intellectually justified candidate for the Botany Scientist Excellence Award, especially if the award recognizes cross-disciplinary excellence or epigenetic insights with botanical significance. If the award committee values conceptual innovation with plant science implications over strict taxonomic boundaries, Prof. Rassoulzadegan is not only suitable but exemplary.
Publications Top Noted
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LncRNA TERRA in hybrid with DNA is a relevant biomarker for monitoring patients with meningioma
Scientific Reports, 2025
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RNA-Mediated Non-Mendelian Inheritance in Mice: The Power of Memory
Biomolecules, 2025
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Impact of mild traumatic brain injury (mTBI) on sperm genome integrity: insights from a mouse model
Journal of Endocrinological Investigation, 2025
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Psoriatic skin transcript phenotype: androgen/estrogen and cortisone/cortisol imbalance with increasing DNA damage response
Molecular Biology Reports, 2024 — 1 citation
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Experimentally altering microRNA levels in embryos alters adult phenotypes
Scientific Reports, 2024 — 1 citation
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Autism-Related Cc2d1a Heterozygous Mice: Increased Levels of miRNAs Retained in DNA/RNA Hybrid Profiles (R-Loop)
Biomolecules, 2024
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Trans Species RNA Activity: Sperm RNA of the Father of an Autistic Child Programs Glial Cells and Behavioral Disorders in Mice
Biomolecules, 2024 — 5 citations
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RNA-Mediated Inheritance of Mammalian Spermatozoa (Book Chapter)
Year not specified
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Alterations in serum mir-126-3p levels over time: A marker of pituitary insufficiency following head trauma
Neuroendocrinology, 2023 — 3 citations
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From Data to Insights: Machine Learning Empowers Prognostic Biomarker Prediction in Autism
Journal of Personalized Medicine, 2023 — 6 citations